Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

SMURF2, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511945

Catalog No. PIPA511945

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.

This antibody is predicted to react with zebrafish based on sequence homology.
Specifications

Specifications

SMURF2
Polyclonal
Unconjugated
SMURF2
Purified
SMURF2
KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human SMURF2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Murine
Immunohistochemistry, Western Blot
0.5mg/mL
PBS with 0.09% sodium azide
Q9HAU4, A2A5Z6
Smad ubiquitination regulatory factor 2, Ubiquitin--protein ligase SMURF2, Smad-specific E3 ubiquitin ligase 2, hSMURF2
Rabbit
IgG
400μL
Store at 2°-8°C for up to 6 months. For long term storage store at -20°C
Primary
64750
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit