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SMURF2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511946

Catalog No. PIPA511946

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Specifications

Specifications

SMURF2
Polyclonal
PBS with 0.09% sodium azide
Q9HAU4
E3 ubiquitin-protein ligase SMURF2; Smad ubiquitination regulatory factor 2; Smad-specific E3 ubiquitin ligase 2;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
64750
Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
SMURF2
Liquid
SMURF2
KLH conjugated synthetic peptide between 702-731 amino acids from the C-terminal region of human SMURF2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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