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SNAI2/Slug Mouse, Unlabeled, Clone: S43-1259, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564614

Catalog No. BDB564614


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Description

Description

The S43-1259 monoclonal antibody specifically recognizes SNAI2, also named Slug, which is a zinc finger transcriptional repressor first recognized for its roles in embryogenesis. SNAI2/Slug and other members of the snail family of transcription factors inhibit the expression of E-cadherin, which plays important roles in cell adhesion and in the maintenance of tissue structure. SNAI2/Slug activation and E-cadherin inhibition induces epithelial-mesenchymal transition (EMT) at several stages of embryonic development and also contributes to the invasiveness of malignancies. Aberrant expression of SNAI2/Slug has also been linked to cancer stem cell formation, cell cycle regulation and apoptosis. SNAI2/Slug is a downstream effector of various signaling pathways, including Akt, Wnt and SCF/ckit signaling.

Specifications

Specifications

SNAI2/Slug
S43-1259
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
50μg
Store undiluted at 4°C
Monoclonal
Flow Cytometry
0.5mg/mL
Snai2; SLUG; Slugh; SLUGH
Affinity Purified
Human SNAI2 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human, Murine
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