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SNAP alpha Mouse anti-Bovine, Human, Rat, Clone: 4E4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112452
A suggested positive control for this product is rat brain lysate.SNAPs (solubleNSFattachment proteins), acting in concert with SNAREs ( S N A P r e c eptors) and the N - ethylmaleimide- s e nsitive f u sion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-toendosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
|Human a-SNAP protein.|
|Bovine, Human, Rat|
|Immunoprecipitation, Western Blot|
|PBS with 50% glycerol and no preservative; pH 7.5|
|P81125, P54920, P54921|
|Synaptosomal-Associated Protein alpha|
|-20° C, Avoid Freeze/Thaw Cycles|
|140673, 518407, 8775|