SNAP23 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528936
PA5-28936 targets SNAP23 in IF and WB applications and shows reactivity with Human samples. The PA5-28936 immunogen is recombit protein fragment corresponding to a region within amino acids 1 and 108 of Human SNAP23. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
|Recombit protein fragment corresponding to a region within amino acids 1 and 108 of Human SNAP23|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|HsT17016, SNAP-23, SNAP23A, SNAP23B, synaptosomal-associated protein 23, vesicle-membrane fusion protein SNAP-23|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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