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SNX2 Rabbit anti-Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523281

Catalog No. PIPA523281


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Description

Description

Snx2 is a signaling protein belonging to the sorting nexin family and characterized by the presence of a 100 amino acid region known as the phox (PX) homology domain (a phosphoinositide binding domain). As a transport carrier Snx2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway. The retromer complex that is composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, Snx1 and Snx2, is required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Though Snx2 associates with formin-binding protein 17, its function is yet unknown. It may form oligomeric complexes with itself as well as with other family members Snx1, Snx1A, and Snx4, but not with Snx3 and is ubiquitously expressed in most tissues, including peripheral leukocytes.
Specifications

Specifications

Snx2
Polyclonal
Unconjugated
SNX2
Liquid
SNX2
Synthetic peptide (356 DHTALSRALSQLAEVEEK 373) of Snx2 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Marsupial, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q2TBW7, O60749, Q9CWK8
TRG9, TRG-9, sorting nexin-2, transformation-related gene 9 protein
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100073099, 474657, 509769, 6643, 67804
Documents
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