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SOCS3, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA139477

Catalog No. PIPA139477

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family recognized. They are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is placenta or testis tissue.
Specifications

Specifications

SOCS3
Polyclonal
TBS with 1% BSA and <0.1% sodium azide; pH 7.6
O14543
CIS-3, STAT-induced STAT inhibitor 3, cytokine-induced SH2 protein 3, cytokine-inducible SH2 protein 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3
Rabbit
IgG
7mL
4° C, do not freeze
Primary
9021
Immunohistochemistry (Paraffin)
Unconjugated
SOCS3
Liquid
SOCS3
Synthetic peptide corresponding to C-terminus of human SOCS-3 protein
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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