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SOCS1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527239

Catalog No. PIPA527239


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Description

Description

PA5-27239 targets SOCS1 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27239 immunogen is a synthetic peptide corresponding to a region within amino acids 149 and 211 of SOCS1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Specifications

Specifications

SOCS1
Polyclonal
Unconjugated
SOCS1
Liquid
SOCS1
Synthetic peptide contain a sequence corresponding to a region within amino acids 149 and 211 of SOCS1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
O15524, O35716
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, JAK binding protein, JAK-binding protein, STAT induced SH3 protein 1, STAT-induced STAT inhibitor 1, TIP-3, Tec-interacting protein 3, cytokine-inducible SH2 protein 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
12703, 8651
Documents
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