SOCS3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528098
PA5-28098 targets SOCS3 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28098 immunogen is synthetic peptide corresponding to a region within amino acids 163 and 225 of Human SOCS3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
|Synthetic peptide corresponding to a region within amino acids 163 and 225 of Human SOCS3|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 40% glycerol and 0.01% thimerosal; pH 7|
|ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, CIS-3, STAT-induced STAT inhibitor 3, cytokine-induced SH2 protein 3, cytokine-inducible SH2 protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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