SLC24A2 Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1926
Sodium/calcium-potassium exchanger proteins (NCKX1) have been reported to occur in retinal photoreceptors and in brain (NCKX2). Unlike the abundant and widely expressed sodium/calcium exchanger which catalyzes the exchange of 3 sodium ions for 1 calcium ion to modulate intracellular calcium levels, NCKX isoforms exchange 4 sodium ions for 1 calcium and 1 potassium ion. The sodium/calcium-potassium exchanger uses the transmembrane sodium gradient to catalyze countertransport of calcium in a potassium-dependent mechanism against its electrochemical gradient. It is hypothesized that NCKX2 plays a significant role in calcium homeostasis and the regulation of neuronal function.PA1-926 detects rat sodium/calcium-potassium exchanger (NCKX2) overexpressed in HEK cells transfected with the rat gene.PA1-926 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects a 78kDa protein representing recombinant rat NCKX2. Immunohistochemical staining of rat NCKX2 in HEK cells transfected with the rat gene with PA1-926 results in staining of the plasma membrane.PA1-926 immunizing peptide corresponds to amino acid residues 90-102 from rat NCKX2. This sequence is predicted to be on the extracellular side of the plasma membrane. PA1-926 immunizing peptide (Cat. # PEP-031) is available for use in neutralization and control experiments.
|Synthetic Peptide: D(90) L N D K I R D Y T P Q P(102)|
|Antigen affinity chromatography|
|Immunohistochemistry (Frozen), Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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