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SLC24A2 Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1926

Catalog No. PA1926

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Sodium/calcium-potassium exchanger proteins (NCKX1) have been reported to occur in retinal photoreceptors and in brain (NCKX2). Unlike the abundant and widely expressed sodium/calcium exchanger which catalyzes the exchange of 3 sodium ions for 1 calcium ion to modulate intracellular calcium levels, NCKX isoforms exchange 4 sodium ions for 1 calcium and 1 potassium ion. The sodium/calcium-potassium exchanger uses the transmembrane sodium gradient to catalyze countertransport of calcium in a potassium-dependent mechanism against its electrochemical gradient. It is hypothesized that NCKX2 plays a significant role in calcium homeostasis and the regulation of neuronal function.

PA1-926 detects rat sodium/calcium-potassium exchanger (NCKX2) overexpressed in HEK cells transfected with the rat gene.PA1-926 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects a 78kDa protein representing recombinant rat NCKX2. Immunohistochemical staining of rat NCKX2 in HEK cells transfected with the rat gene with PA1-926 results in staining of the plasma membrane.PA1-926 immunizing peptide corresponds to amino acid residues 90-102 from rat NCKX2. This sequence is predicted to be on the extracellular side of the plasma membrane. PA1-926 immunizing peptide (Cat. # PEP-031) is available for use in neutralization and control experiments.
Specifications

Specifications

SLC24A2
Polyclonal
Unconjugated
Slc24a2
Liquid
SLC24A2
Synthetic Peptide: D(90) L N D K I R D Y T P Q P(102)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Rat
Immunohistochemistry (Frozen), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
O54701
NCKX2
Rabbit
IgG
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
84550
Documents
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