SSTR1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3108
PA3-108 detects the Somatostatin Receptor 1 in human samples. PA3-108 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR1 transfected HEK-293 cells this antibody detects a ~52-63 kDa protein representing SSTR1. The PA3-108 immunogen is a synthetic peptide corresponding to residues C(380) R N G T C T S R I T T L(391) of human SSTR1.The Somatostatin Receptor Type 1 (SSTR1) has been reported at highest levels in the jejunum and stomach. In addition, SSTR1 has been shown to be expressed in adrenal, brain, eye, and panreas. ESTs have been isolated from normal placenta and colon cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
|whole serum with 0.05% sodium azide|
|Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide corresponding to residues C(380) R N G T C T S R I T T L(391) of human SSTR1.|
|-20° C, Avoid Freeze/Thaw Cycles|
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