Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

SSTR2 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3109

Catalog No. PA3109


Add to cart

Description

Description

PA3-109 detects Somatostatin Receptor 2A in human and rat samples. PA3-109 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR2A transfected HEK-293 cells this antibody detects a ~62-72 kDa protein representing SSTR2A. The PA3-109 immunogen is a synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.

Somatostatin Receptor Type 2 (SST2) expression has been reported in adrenal, aorta, brain, breast, eye, gastrointestinal tract, pancreas, prostate, spinal cord, and thyroid. ESTs have been isolated from brain, eye, head/neck, kidney, lymph node, pineal, and prostate libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Specifications

Specifications

SSTR2
Polyclonal
whole serum with 0.05% sodium azide
P30874, P30680
SSTR2A
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SSTR2
Liquid
SSTR2
Synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54305, 6752
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit