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Sorcin Rabbit anti-Bovine, Canine, Equine, Human, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523143

Catalog No. PIPA523143


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Description

Description

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.
Specifications

Specifications

Sorcin
Polyclonal
Unconjugated
SRI
Liquid
SRI
Synthetic peptide (60 QSGIAGGYKPFNLET 74) of Sorcin protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P30626, Q6P069
CP-22, CP22, SCN, V19, 22 kDa protein, H_RG167B05.1, calcium binding protein amplified in mutlidrug-resistant cells
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100059619, 109552, 475220, 508319, 6717
Documents
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