Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Sos1 Mouse, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610095

 View more versions of this product

Catalog No. BDB610095

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



The Sos (son of sevenless) gene was originally identified in Drosophila, and two mammalian homologues (mSos1 and mSos2) were isolated from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both mSos1 and mSos2 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues, hSos1 and hSos2 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170kDa, presumably due to a high proline content. The mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras.

Host Species: Mouse
Clone: 25
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse mSos1 aa. 1-109
Formula Weight [Chemical]: 170kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse mSos1 aa. 1-109
50 μg
Cell Biology
Canine, Human, Mouse, Rat
Western Blot
Affinity Purified
Store undiluted at -20°C.


Product Certifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.