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SOX1 Rabbit anti-Canine, Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523370

Catalog No. PIPA523370


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Description

Description

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
Specifications

Specifications

SOX1
Polyclonal
Unconjugated
SOX1
Liquid
SOX1
Synthetic peptide (366 SRLHSLPQHYQGAGA 380) of SOX1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
O00570, P53783
SRY-related HMG-box gene 1, transcription factor SOX-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
20664, 607464, 6656
Documents
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