Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

SFTPD Mouse anti-Human, Rat, Clone: IIIH3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140246

Catalog No. 01-676-579


Add to cart

Description

Description

MA1-40246 detects SP-D from rat and human samples. MA1-40246 has been successfully used in ELISA, Western blot and immunohistochemistry (paraffin) applications. The MA1-40246 immunogen is rat SP-D.

Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular  ft.head ft. regions linked by triple-helical, collagen-like, strands. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Group III of the family of C-type lectins also includes SP-A and the serum proteins man-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
Specifications

Specifications

SFTPD
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P35247, P35248
surfactant protein D, SFTPD
Mouse
IgG1
100 μg
4° C
Primary
25350, 6441
ELISA, Immunohistochemistry (Paraffin), Western Blot
IIIH3
Unconjugated
SFTPD
Liquid
SFTPD
Rat SP-D.
Protein G
RUO
Antibody
Monoclonal
Human, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit