SFTPD Mouse anti-Human, Rat, Clone: IVG8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140248
MA1-40248 detects SP-D from rat and human samples. MA1-40248 has been successfully used in ELISA, Western blot and immunohistochemistry (paraffin) applications. The MA1-40248 immunogen is rat SP-D.Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular ft.head ft. regions linked by triple-helical, collagen-like, strands. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Group III of the family of C-type lectins also includes SP-A and the serum proteins man-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
|PBS with 0.1% BSA and 0.02% sodium azide|
|surfactant protein D, SFTPD|
|ELISA, Immunohistochemistry (Paraffin), Western Blot|
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