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SPARC Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112865

Catalog No. 01-675-845


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Description

Description

This antibody may cross react with SPARCL1. A suggested positive control for this product is mouse heart lysate.

SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 ft.-UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).
Specifications

Specifications

SPARC
Polyclonal
PBS with 0.08% sodium azide
P09486
ON
Rabbit
IgG
70 μg
-80° C, Avoid Freeze/Thaw Cycles
Primary
6678
ELISA, Immunohistochemistry, Western Blot
Unconjugated
SPARC
Liquid
SPARC
Synthetic peptide corresponding to human SPARC.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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