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SPG11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520683

Catalog No. PIPA520683


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Description

Description

A suggested positive control is mouse heart tissue lysate. PA5-20683 can be used with blocking peptide PEP-0799.

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.  Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
Specifications

Specifications

SPG11
Polyclonal
Unconjugated
SPG11
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
214585, 311372, 80208
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96JI7, Q3UHA3
SPG11
A 15 amino acid synthetic peptide near the carboxy terminus of human SPG11
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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