EDG6 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523221
DescriptionEdg6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), which are structurally related lysophospholipid mediators. Binding of SPP to Edg6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein also acts as a receptor for a lipid-derived ligand. Edg6 plays an essential role in lymphocyte cell signaling. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human Edg6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker.
|Synthetic peptide (23 RLIVLHYNHSGRLAGRGG 40) of Sphingolipid Receptor Edg6/S1P4 protein.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% sodium azide|
|EDG6, LPC1, S1P4, SLP4, S1P receptor 4, S1P receptor Edg-6, endothelial differentiation G-protein coupled receptor 6, endothelial differentiation, G protein coupled receptor 6, endothelial differentiation, G-protein-coupled receptor 6, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6, sphingosine 1-phosphate receptor 4, sphingosine 1-phosphate receptor Edg-6|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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