EDG8 Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523195
DescriptionSphingosine 1-phosphate receptor Edg8 is a multi-pass membrane protein belonging to the G-protein coupled receptor 1 family and coupled to both the G (i/0) alpha and G (12) subclass of heteromeric G-proteins. Edg8 acts as a receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) as well as for lysolipid mediator lysophosphatidic acid (LPA) and gives diverse physiological effect on most types of cells and tissues. Edg8 may also play a regulatory role in the transformation of radial glial cells into astrocytes and affect proliferative activity of these cells. It is widely expressed in white matter tracts of brain, spleen, peripheral blood leukocytes, placenta, lung, aorta, and fetal spleen. Over expression of Edg8 leads to a lymphoproliferative disorder often associated with the autoimmune disease known as leukemic large granular lymphocyte (LGL).
|Synthetic peptide (15 IVLHYNYTGKLRGARYQ 31) of Sphingolipid Receptor Edg8/S1P5 protein.|
|Canine, Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q9H228, Q91X56, Q9JKM5|
|EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, S1P receptor 5, S1P receptor Edg-8, endothelial differentiation G-protein-coupled receptor 8, endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, sphingosine 1-phosphate receptor 5, sphingosine 1-phosphate receptor EDG8, sphingosine 1-phosphate receptor Edg-8|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|53637, 60399, 610828, 94226|
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