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SGPP2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112724

Catalog No. PIPA112724


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Description

Description

By Western blot, PA1-12724 detects a ~45 kDa protein representing S1P Phosphatase 2 from human brain lysate.

Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1–5)/Gprotein- coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family whichplay a role in attenuating intracellular S1P signaling.
Specifications

Specifications

SGPP2
Polyclonal
whole serum with no preservative
Q8IWX5
FLJ39004, SPP2
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Western Blot
Unconjugated
SGPP2
Liquid
SGPP2
Synthetic peptide corresponding to sphingosine 1-phosphate phosphatase 2.
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles
Primary
130367
Documents
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