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SPHK1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528099

Catalog No. PIPA528099


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Description

Description

PA5-28099 targets SPHK1 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28099 immunogen is synthetic peptide corresponding to a region within amino acids 321 and 384 of Human SPHK1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.
Specifications

Specifications

SPHK1
Polyclonal
Unconjugated
SPHK1
Liquid
SPHK1
Synthetic peptide corresponding to a region within amino acids 321 and 384 of Human SPHK1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Q9NYA1
SPHK, SK 1, SPK 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8877
Documents
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