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SPHK2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514070

Catalog No. PIPA514070


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Description

Description

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
Specifications

Specifications

SPHK2
Polyclonal
PBS with 0.09% sodium azide
Q9NRA0
Sphingosine kinase 2, SK 2, SPK 2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
56848
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SPHK2
Liquid
SPHK2
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SPHK2
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
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