Syk Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19104
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcgamma receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.
|Internal sequence corresponding to amino acids C-KYLQQNRHVKDKN.|
|Antigen affinity chromatography|
|peptide-ELISA, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|SP1; Sp1 transcription factor ; HGNC:11205|
|-20° C, Avoid Freeze/Thaw Cycles|
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