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Osteopontin Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19076

Catalog No. 01-674-660


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Description

Description

This antibody is predicted to react with canine, mouse and rat based on sequence homology.

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Specifications

Specifications

Osteopontin
Polyclonal
Unconjugated
SPP1
Liquid
SPP1
Synthetic peptide corresponding to the C terminus amino acids DPKSKEEDKHLK.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P10451
SPP1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); HGNC:11255; BNSP; BSPI; ETA-1; MGC110940; OPN ; S
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
6696
Documents
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