Osteopontin Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19076
This antibody is predicted to react with canine, mouse and rat based on sequence homology.Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
|Synthetic peptide corresponding to the C terminus amino acids DPKSKEEDKHLK.|
|Antigen affinity chromatography|
|peptide-ELISA, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|SPP1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); HGNC:11255; BNSP; BSPI; ETA-1; MGC110940; OPN ; S|
|-20° C, Avoid Freeze/Thaw Cycles|
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