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Osteopontin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513494

Catalog No. PIPA513494


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Description

Description

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
Specifications

Specifications

Osteopontin
Polyclonal
Unconjugated
SPP1
Liquid
SPP1
KLH conjugated synthetic peptide between 273-301 amino acids from the C-terminal region of human SPP1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
1.7 mg/mL
PBS with 0.09% sodium azide
P10451
Osteopontin; Bone sialoprotein 1; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Nephropontin; Uropontin; OPN; BNSP; SPP1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6696
Documents
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