SPTLC1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521141
A suggested positive control is human lung tissue lysate. PA5-21141 can be used with blocking peptide PEP-1255.Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5 ft.-phosphate as a cofactor. SPT1 is the long chain base subunit 1 of mammalian serine palmitoyltransferase. SPT1 is not catalytically active but is necessary for the stabilization of the SPT2 subunit and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. Missense mutations in this gene have been identified in patients with hereditary sensory neuropathy type 1 (HSAN1). These mutations induce a shift in the substrate specificity of the holoenzyme, leading to the formation and accumulation of two neurotoxic sphingolipids.
|A 17 amino acid peptide near the carboxy terminus of human SPT1.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-118F2.1, HSAN, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, hLCB1; LCB 1; SPT 1; long chain base biosynthesis protein 1; serine C-palmitoyltransferase; serine palmitoyltransferase 1; serine-palmitoyl-CoA transferase 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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