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SPTLC2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521142

Catalog No. PIPA521142

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A suggested positive control is NIH-3T3 cell lysate. PA5-21142 can be used with blocking peptide PEP-1256.

Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5 ft.-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.


A 15 amino acid peptide near the carboxy terminus of human SPT2.
Antigen affinity chromatography
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O15270, P97363
HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a; LCB 2; SPT 2; long chain base biosynthesis protein 2a; serine palmitoyltransferase 2; serine palmitoyltransferase, subunit II; serine-palmitoyl-CoA transferase 2
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
20773, 366697, 9517
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