SPTLC2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521142
A suggested positive control is NIH-3T3 cell lysate. PA5-21142 can be used with blocking peptide PEP-1256.Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5 ft.-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
|A 15 amino acid peptide near the carboxy terminus of human SPT2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a; LCB 2; SPT 2; long chain base biosynthesis protein 2a; serine palmitoyltransferase 2; serine palmitoyltransferase, subunit II; serine-palmitoyl-CoA transferase 2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|20773, 366697, 9517|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok