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SQSTM1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512092

Catalog No. PIPA512092


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
Specifications

Specifications

SQSTM1
Polyclonal
PBS with 0.09% sodium azide
Q13501
Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1, ORCA, OSIL
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8878
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SQSTM1
Liquid
SQSTM1
KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human SQSTM1 (p62)
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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