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CD254 (RANK Ligand) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520291

Catalog No. PIPA520291


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Description

Description

A suggested positive control is rat liver tissue lysate. PA5-20291 can be used with blocking peptide PEP-0421.

The receptor activator of NF-kappa-B ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.
Specifications

Specifications

CD254 (RANK Ligand)
Polyclonal
Unconjugated
TNFSF11
Liquid
TNFSF11
A 14 amino acid peptide from near the center of human sRANK-L.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O14788, O35235, Q9ESE2
RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
117516, 21943, 8600
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