SRC-1 Mouse, Unlabeled, Clone: 8, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612378
Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear hormone receptors are ligand-activated transcription factors that modulate target gene expression.These ligand/receptor complexes also interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified, including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1α and -1β. SRC-1 is a member of the basic helix-loop-helix-PAS domain family. It contains an N-terminal basic-helix-loop-helix (bHLH), two N-terminal PAS domains, and a glutamine-rich region near the C-terminus. SRC-1 interacts with many different steroid receptors and recruitment of SRC-1 to promoter sites may facilitate opening of chromatin structure via its histone acetyltransferase activity, as well as stabilization of the preinitiation complex. ERK-2 can phosphorylate SRC-1 at threonine and serine sites in vitro. In addition, SRC-1 expression in cells stimulated with EGF enhances
progesterone receptor-mediated activation of a target reporter gene. Thus, SRC-1 is an important transcriptional co-activator involved in steroid receptor signaling.
Immunofluorescence, Western Blotting
|Human SRC-1 aa. 761-863|
|Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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