SRPX Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520843
A suggested positive control is SK-N-SH cell lysate. PA5-20843 can be used with blocking peptide PEP-0957.SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and maligt tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
|A 13 amino acid peptide from near the amino terminus of human SRPX1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P78539, Q9R0M3, Q63769|
|DRS, ETX1, SRPX1; sushi repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-linked|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|51795, 64316, 8406|
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