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SRPX Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520843

Catalog No. PIPA520843


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Description

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20843 can be used with blocking peptide PEP-0957.

SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and maligt tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
Specifications

Specifications

SRPX
Polyclonal
Unconjugated
SRPX
Liquid
SRPX
A 13 amino acid peptide from near the amino terminus of human SRPX1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P78539, Q9R0M3, Q63769
DRS, ETX1, SRPX1; sushi repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-linked
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
51795, 64316, 8406
Documents
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