ST3GAL6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520748
A suggested positive control is Hela cell lysate. PA5-20748 can be used with blocking peptide PEP-0862.Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determits of carbohydrate structures, such as the sialyl-Lewis X determits, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
|A 16 amino acid peptide from near the carboxy terminus of human ST3gal6.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9Y274, Q8VIB3, P61943|
|SIAT10, ST3GALVI; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; alpha2,3-sialyltransferase; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); type 2 lactosamine alpha-2,3-sialyltransferase|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|10402, 304023, 54613|
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