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STAM Mouse anti-Human, Clone: 29C678, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141179

Catalog No. 01-676-585


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Description

Description

Suggested positive control: 293 whole cell lysate, Hela whole cell lysate.

STAM is a signal transducing adaptor molecule, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a domit-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors.
Specifications

Specifications

STAM
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q92783
DKFZp686J2352, STAM1
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8027
Western Blot
29C678
Unconjugated
STAM
Liquid
STAM
Synthetic peptide corresponding to residues 149-165 of human STAM.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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