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STARD3 Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1562

Catalog No. PA1562


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Description

Description

PA1-562 detects MLN64 from rat tissues. PA1-562 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~53 kDa protein representing MLN64 from rat adrenal gland tissue extracts. This antibody also detects an ~25 kDa protein from rat adrenal gland which may correspond to degradation product. PA1-562 antigen is recombit MLN64 protein.

The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR ft.s steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.
Specifications

Specifications

STARD3
Polyclonal
Unconjugated
Stard3
StAR-related lipid transfer protein 3, StARD3, CAB1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
363675
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Liquid
STARD3
Recombit MLN64 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Rat
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