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STAT1 Rabbit anti-Canine, Human, Mouse, Non-human primate, Porcine, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141383

Catalog No. 01-675-512


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Description

Description

This antibody is predicted to react in chicken and rat samples based on sequence homology. This sequence is 100% conserved between Stat1 alpha and Stat1 beta. Suggested positive control: Hela whole cell extract, HeLa cell lysate.

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
Specifications

Specifications

STAT1
Polyclonal
Unconjugated
STAT1
Liquid
STAT1
Synthetic peptide corresponding to residues E(711) V H P S R L Q T T D N L L P M S P E E(730) of human Stat1.
Protein G
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate, Porcine
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P42224, P42225, Q764M5
DKFZp686B04100, ISGF-3, STAT91
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
20846, 396655, 488449, 6772
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