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anti-STAT4 Clone: 2H9L5, Invitrogen™

STAT4 Monoclonal antibody 700185 from Thermo Scientific™ Pierce™ specifically detects STAT4 in Human, Mouse and Rat samples, and it is validated for WB, IF, ICC, IHC (P), FACS and ELISA

Manufacturer:  Invitrogen 700185

Encompass

Catalog No. 70-018-5


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Description

Description

Signal transducer and activator of transcription 4 (STAT4) was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT 1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. Until recently the cytokine(s) responsible for activation of STAT4 had not been identified. STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12). IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections. In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens. Perhaps not surprisingly, STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells. A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.

700185 detects STAT4 in Human, Mouse and Rat samples. 700185 has been successfully used in WB, IF, ICC, IHC (P), FACS and ELISA procedures. The immunogen for 700185 is a peptide corresponding to amino acids 730-748 of Q14765.

Applications:

ELISA, FACS, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blotting

Specifications

Specifications

STAT4
Unconjugated
P42228, Q14765
Rabbit
IgG
Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.
Monoclonal
Human, Murine, Rat
2H9L5
100μg of Protein A antibody in PBS with 0.09% sodium azide;
Purified
A peptide corresponding to amino acids 730-748 of Q14765.
Protein A
Primary
20849, 6775
SDS
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