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Stat4 (pY693) Mouse, Unlabeled, Clone: 38/P-STAT4, BD

Mouse Monoclonal Antibody

$310.00 - $530.00

Specifications

Antigen Stat4 (pY693)
Isotype IgG2b, κ
Immunogen Phosphorylated Human Stat4 (pY693)
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612738
View Documents
BD Biosciences
612738
50μg
Each for $310.00
Add to cart
 
BDB612739
View Documents
BD Biosciences
612739
150μg
Each for $530.00
Add to cart
 
Description

Description

The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNγ in response to treatment with IL-12. IFNγ plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.

Western Blotting

Specifications

Specifications

Stat4 (pY693)
Phosphorylated Human Stat4 (pY693)
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2b, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
38/P-STAT4
250μg/mL
SDS
Product Certifications

For Research Use Only.

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