Stat5 (pY694) Rabbit anti-Human, Unlabeled, Polyclonal, BD
Rabbit Polyclonal Antibody
Manufacturer: BD Biosciences 611818
Mammary gland factor (MGF) has been shown to play a critical role in the lactogenic hormone response and has been well characterized in mammary epithelial cells. The SH3 domain of MGF shows extensive homology with the SH2 domains of Stat1 and Stat2. This homology leads to speculation that MGF may have a broader physiological role than originally anticipated and has led to its classification as a member of the Stat family. Stat5 (MGF) mRNA expression is highest in mammary gland tissue. Lower levels are found in ovary, thymus, spleen, kidney, lung, muscle, and the adrenal gland. The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response. There are at least three forms of PRLR; however, only the long form is able to activate the 92kDa Stat5 protein by inducing phosphorylation at Tyr694. Once phosphorylated, Stat5 becomes an essential transcription factor which binds to the β-casein gene promoter. Stat5 activity is tightly regulated throughout gestation,lactation, and post-lactation. Treatment of activated Stat5 with a protein tyrosine phosphatase results in the loss of DNA binding activity. The presence of an SH2 domain within Stat5 suggests that it may directly interact with protein tyrosine kinases (PTKs) such as JAK2.
Host Species: Rabbit
Clone: xSpecies Reactivity [for Features Main]: Human
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
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