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STAT6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA138675

Catalog No. 01-673-793


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Description

Description

This antibody is predicted to react with canine, mouse, porcine, rabbit based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta or tonsil tissue.

STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
Specifications

Specifications

STAT6
Polyclonal
PBS with 1% BSA and 0.1% sodium azide; pH 7.6
P42226
D12S1644, IL-4-STAT, STAT6B, STAT6C, STAT, interleukin4-induced, signal transducer and activator of transcription 6, transcription factor IL-4 STAT
Rabbit
IgG
1 mL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6778
Immunohistochemistry (Paraffin)
Unconjugated
STAT6
Liquid
STAT6
Synthetic peptide derived from C-terminus of human STAT6.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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