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STEAP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520403

Catalog No. PIPA520403


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Description

Description

A suggested positive control is human spleen tissue lysate. PA5-20403 can be used with blocking peptide PEP-0520.

The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.
Specifications

Specifications

STEAP1
Polyclonal
Unconjugated
STEAP1
Liquid
STEAP1
An 18 amino acid peptide from near the carboxy terminus of human STEAP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UHE8, Q9CWR7
tcag7.1170, PRSS24, STEAP; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
26872, 297738, 70358
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