STI1 Mouse, Unlabeled, Clone: 28, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610834
Progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. The human Stress-Inducible protein 1 (STI1) was identified from SV40-transformed MRC-5 fibroblasts and shares 42% homology with stress-inducible mediator for the heat shock response in yeast. STI1, which contains the tetratricopeptide (TPR) motif widely represented in proteins required for mitosis and RNA synthesis, is induced in SV40-transformed cells and by heat shock. STI1 was also detected in macromolecular complexes with the heat shock proteins HSP70, 84/86, and 90. Further studies showed that STI1 helps in the maturation of several protein targets of HSP90. Immunolocalization analysis localized STI1 within the nucleus of transformed cells, whereas the same protein was found in the Golgi region of normal cells.
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human STI1 aa. 22-143|
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