STIM1 Mouse anti-Human, Mouse, Rat, Clone: CDN3H4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119451
DescriptionSTIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
|PBS with 15mM sodium azide; pH 7.4|
|Q13586, P70302, P84903|
|4° C, do not freeze|
|20866, 361618, 6786|
|Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Synthetic peptide corresponding to the C-terminal cytoplasmic part of STIM1|
|Human, Mouse, Rat|
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