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STIM1 Mouse anti-Human, Mouse, Rat, Clone: CDN3H4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119451

Catalog No. 01-676-186


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Description

Description

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
Specifications

Specifications

STIM1
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
Q13586, P70302, P84903
D11S4896E, GOK
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
20866, 361618, 6786
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
CDN3H4
Unconjugated
STIM1
Liquid
STIM1
Synthetic peptide corresponding to the C-terminal cytoplasmic part of STIM1
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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