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STIM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520371

Catalog No. PIPA520371


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Description

Description

A suggested positive control is mouse thymus tissue lysate. PA5-20371 can be used with blocking peptide PEP-0488.

In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least two isoforms of STIM1 are known to exist; this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.
Specifications

Specifications

STIM1
Polyclonal
Unconjugated
STIM1
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20866, 361618, 6786
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13586, P70302, P84903
STIM1
A 24 amino acid peptide from near the carboxy terminus of human STIM1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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