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STING Mouse anti-Human, Brilliant Violet 421, Clone: T3-680, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564966

Catalog No. BDB564966


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Description

Description

The T3-680 monoclonal antibody specifically recognizes human STING (Stimulator of interferon genes protein) which is also known as Endoplasmic reticulum interferon stimulator (ERIS) and Mediator of IRF3 activation (MITA). STING is encoded by TMEM173 (Transmembrane protein 173). STING is a multi-pass transmembrane adaptor protein which is expressed in the endoplasmic reticulum of cells. STING acts as a sensor of cytosolic double-stranded DNA derived from bacteria and viruses and promotes the production of type I interferons, IFN- α and IFN- β . Following activation, STING translocates with TBK1kinase to perinuclear endosomes. The TBK1 kinase phosphorylates and activates interferon regulatory factors, such as IRF3, and NF-κB, which leads to the induction of type I interferon and other immune response genes that play roles in innate and adaptive immunity.

Specifications

Specifications

STING
T3-680
hSTING; MITA; hMITA; ERIS; MPYS; NET23; TM173; TMEM173
Affinity purified
Human STING Recombinant Protein
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide
Murine
IgG1, κ
RUO
Primary
Human
Documents
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