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STK29 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514009

Catalog No. PIPA514009

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C, and CDC25B in an in vitro assay, but a kinase-dead mutant does not. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 induces G2/M arrest in HeLa cells. Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest. BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.
Specifications

Specifications

STK29
Polyclonal
PBS with 0.09% sodium azide
Q8IWQ3
BR serine/threonine-protein kinase 2; Serine/threonine-protein kinase 29; SAD1B; BRSK2; PEN11B, STK29
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9024
Immunohistochemistry, Western Blot
Unconjugated
BRSK2
Liquid
BRSK2
KLH conjugated synthetic peptide between 706-736 amino acids from the C-terminal region of human STK29
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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