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SUMO1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118267

Catalog No. 01-670-520


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Description

Description

PA1-18267 detects SUMO1 from human and rat samples. PA1-18267 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18267 immunogen is a synthetic peptide corresponding to residues A(6) K P S T E D L G D K K E G E Y(21) of human SUMO-1, conjugated to diphtheria toxoid. The sequence is 100% conserved in rat. Reconstitute with 100 µL of distilled water.

SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.
Specifications

Specifications

SUMO1
Polyclonal
whole serum with no preservative
P63165, Q5I0H3
Sentrin-1, UBL1, SMT3H3, GMP1, SMT3, Small Ubiquitin Related Modifier-1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry, Western Blot
Unconjugated
SUMO1
Lyophilized
SUMO1
Synthetic peptide corresponding to residues A(6) K P S T E D L G D K K E G E Y(21) of human SUMO-1.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
301442, 7341
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