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SFTPA1 Mouse anti-Human, Biotin, Clone: 6F10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen HYB23804B01

Catalog No. HYB23804B01


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Description

Description

HYB 238-04B-01 detects Surfactant protein A in human samples .   HYB 238-04B-01 has been successfully used in ELISA procedures. In Western blotting after SDS-PAGE, HYB 238-04B-01 reacts with reduced forms of SP-A and weaker with non-reduced Forms. In immunohistochemical staining from paraffin embedded tissue samples, HYB 238-04B-01 reacts specifically with human SP-A. Immunoreactivity is seen with alveolar type II cells, nonciliated bronchial cells and a subset of alveolar macrophages. No reactivity in samples from pancreas, intestines, thymus, prostate gland or the peritoneal cavity lining cells. The HYB 238-04B-01 immunogen is native SP-A purified from bronchioaveolar lavage from proteinosis patients. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular  ft.head ft. regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins man-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/mL in healthy individuals.
Specifications

Specifications

SFTPA1
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
Q8IWL2
Pulmonary surfactant-associated protein A, SP-A
Mouse
IgG1, kappa
100 μL
4° C, store in dark
Primary
653509
ELISA
6F10
Biotin
SFTPA1
Liquid
SFTPA1
Native SP-A purified from bronchioaveolar lavage from proteinosis patients.
Purified
RUO
Antibody
Monoclonal
Human
SDS
Documents
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