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Syk Mouse anti-Human, Mouse, Rat, Clone: SYK-01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119332

Catalog No. 01-676-088


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Description

Description

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Specifications

Specifications

Syk
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P43405, P48025, Q64725
Protein tyrosine kinase p72Syk
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
20963, 25155, 6850
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
SYK-01
Unconjugated
SYK
Liquid
SYK
Recombit fragment (aa 5-360) of human Syk.
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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